・胃癌と乳癌（小葉癌）のハイリスク
・E-カドヘリン（CDH1)遺伝子変異の関与が指摘されている
・常染色体優性遺伝
・以下の場合はHDGCを疑う（リンク先より転記）
1) Two or more cases of diffuse gastric cancer in a family, with at least one
diffuse gastric cancer diagnosed before the age of 50 years.
2) Three or more cases of diffuse gastric cancer in a family diagnosed at any
age.
3) An individual diagnosed with diffuse gastric cancer before 35 years of
age.
4) An individual diagnosed with both diffuse gastric cancer and lobular
breast cancer.
5) One family member with diffuse gastric cancer and another with either
lobular breast cancer OR signet ring colon cancer.
関連リンク↓
http://cancer.stanford.edu/patient_care/services/geneticCounseling/HDGC.html
